CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization

  title={CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization},
  author={Dongchu Ma and Yinghui Sun and D. Lin and H. Wang and B. Dai and X. Zhang and W. Ouyang and J. Jian and W. Jia and Xiaoguang Xu and Boquan Jin},
  journal={European Journal of Haematology},
  • Dongchu Ma, Yinghui Sun, +8 authors Boquan Jin
  • Published 2005
  • Medicine, Biology
  • European Journal of Haematology
  • Abstract:  Objectives:  In this study, we examined the expression of CD226 on megakaryocytic, granulocytic and erythroid lineage from hematopoietic stem cells/progenitor cells in adult and fetus and its potential role in megakaryocytic maturation. Methods: CD34+ cells from adult and fetus were induced to differentiate toward the megakaryocytic lineage by thrombopoietin (TPO) and the granulocytic lineage by granulocyte colony‐stimulating factor (G‐CSF), respectively. Mononuclear cells from fetal… CONTINUE READING
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