CD226 (DNAM-1) Is Involved in Lymphocyte Function–associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation

@article{Shibuya2003CD226I,
  title={CD226 (DNAM-1) Is Involved in Lymphocyte Function–associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation},
  author={Kazuko Shibuya and Jun Shirakawa and Tomie Kameyama and Shin-ichiro Honda and Satoko Tahara-Hanaoka and Akitomo Miyamoto and Masafumi Onodera and Takayuki Sumida and Hiromitsu Nakauchi and Hiroyuki Miyoshi and Akira Shibuya},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={1829 - 1839}
}
Upon antigen recognition by the T cell receptor, lymphocyte function-associated antigen 1 (LFA-1) physically associates with the leukocyte adhesion molecule CD226 (DNAM-1) and the protein tyrosine kinase Fyn. We show that lentiviral vector-mediated mutant (Y-F322) CD226 transferred into naive CD4+ helper T cells (Ths) inhibited interleukin (IL)-12-independent Th1 development initiated by CD3 and LFA-1 ligations. Moreover, proliferation induced by LFA-1 costimulatory signal was suppressed in… CONTINUE READING
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