CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.

@article{Otipoby2001CD22RB,
  title={CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.},
  author={Kevin L. Otipoby and Kevin E. Draves and Edward A. Clark},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 47},
  pages={44315-22}
}
Recognition of antigen by the B cell antigen receptor (BCR) determines the subsequent fate of a B cell and is regulated in part by the involvement of other surface molecules, termed coreceptors. CD22 is a B cell-restricted coreceptor that gets rapidly tyrosyl-phosphorylated and recruits various signaling molecules to the membrane following BCR ligation. Although CD22 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs), only the two carboxyl-terminal ITIM tyrosines are… CONTINUE READING
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