CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity

@article{Chen2004CD22AC,
  title={CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity},
  author={Jie Chen and Paul A. McLean and Benjamin G Neel and Gbolahan Okunade and Gary E. Shull and Henry H. Wortis},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={651-657}
}
Binding of antigen to the B cell receptor induces a calcium response, which is required for proliferation and antibody production. CD22, a B cell surface protein, inhibits this signal through mechanisms that have been obscure. We report here that CD22 augments calcium efflux after B cell receptor crosslinking. Inhibition of plasma membrane calcium-ATPase (PMCA) attenuated these effects, as did disruption by homologous recombination of the gene encoding PMCA4a and PMCA4b. PMCA… CONTINUE READING
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