CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody and CD4(+) T cell responses following DNA vaccination of outbred animals.

@article{Njongmeta2012CD205AT,
  title={CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody and CD4(+) T cell responses following DNA vaccination of outbred animals.},
  author={Leo M Njongmeta and Jocelyn Bray and Christopher J Davies and William C. Davis and Chris John Howard and Jayne C Hope and Guy H. Palmer and Wendy C. Brown and Waithaka Mwangi},
  journal={Vaccine},
  year={2012},
  volume={30 9},
  pages={1624-35}
}
Dendritic cell antigen targeting primes robust immune responses in mouse models. Optimizing this immunization strategy in the actual hosts that require protection will advance development of efficacious contemporary vaccines. In a proof-of-concept study, we tested the immunogenicity of a single, low dose of a novel multi-component DNA construct expressing a CD205-targeted antigen fused to a CD40L minimal functional domain for linked DC activation. The DNA construct was formulated with DNA… CONTINUE READING

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