CD200R signaling in tumor tolerance and inflammation: A tricky balance.

@article{Rygiel2012CD200RSI,
  title={CD200R signaling in tumor tolerance and inflammation: A tricky balance.},
  author={Tomasz P. Rygiel and Linde Meyaard},
  journal={Current opinion in immunology},
  year={2012},
  volume={24 2},
  pages={233-8}
}
The inhibitory CD200-CD200 receptor (CD200R) interaction is essential to prevent massive inflammatory responses and immune pathology during microbial infection. Since CD200 expression on human malignancies is associated with tumor progression, CD200 blocking antibodies are currently tested in clinical trials to boost anti-tumor responses. Here we discuss… CONTINUE READING