CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells.

@article{Xu2016CD200FcAI,
  title={CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells.},
  author={Junwei Xu and Lu Lu and Jing Hua Lu and Jihui Xia and Hongjin Lu and Lin Yang and Wensheng Xia and Shihai Shen},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={84},
  pages={714-721}
}
BACKGROUND Recent evidence suggests that CD200 fusion protein (CD200Fc), a CD200R1 agonist may attenuate inflammatory responses in autoimmune diseases and neuro-degeneration. While, little is known about the function of CD200Fc in cigarette smoke extract (CSE)-induced mouse Cardiac Microvascular Endothelial Cells (mCMECs). The present study was designed to elucidate the effects of CD200Fc on CSE-induced vascular endothelial barrier (VEB) dysfunction and inflammatory responses, which is a highly… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis.

Arteriosclerosis, thrombosis, and vascular biology • 2014
View 13 Excerpts
Highly Influenced

Mechanisms of coronary thrombosis in cigarette smoke exposure.

Arteriosclerosis, thrombosis, and vascular biology • 2013
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…