CD20 deficiency in humans results in impaired T cell-independent antibody responses.

@article{Kuijpers2010CD20DI,
  title={CD20 deficiency in humans results in impaired T cell-independent antibody responses.},
  author={Taco W Kuijpers and R J Bende and Paul A. Baars and Annette Grummels and Ingrid A. M. Derks and Koert Melchior Dolman and T. Beaumont and Thomas F. Tedder and Carel J M van Noesel and Ericc Eldering and Ren{\'e} A W van Lier},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 1},
  pages={
          214-22
        }
}
CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 in human B cell physiology has remained elusive. We describe here a juvenile patient with CD20 deficiency due to a homozygous mutation in a splice junction of the CD20 gene (also known as MS4A1) that results in "cryptic" splicing and nonfunctional mRNA species. Analysis of this… CONTINUE READING

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