CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.

@article{Teh1997CD2RT,
  title={CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.},
  author={Swee J. Teh and Nigel Killeen and Alexander Tarakhovsky and Dan R. Littman and Hung Sia Teh},
  journal={Blood},
  year={1997},
  volume={89 4},
  pages={1308-18}
}
The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and immune responses, we have analyzed two lines of CD2-null mice, each expressing a distinct class I major histocompatibility complex (MHC)-restricted T-cell receptor (TCR). In both situations, the absence of CD2 appeared to promote the positive selection of cells in a manner that is similar to that which occurs in the absence of… CONTINUE READING