CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation.

@article{Crawford2003CD2EI,
  title={CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation.},
  author={Keith D Crawford and Aleksandra Stark and Betsy Kitchens and Kerry Sternheim and Vassilios Pantazopoulos and Ellen Triantafellow and Zhigang Wang and Baldev Vasir and Charles E Larsen and Dana Gabuzda and Ellis L. Reinherz and Chester A. Alper},
  journal={Blood},
  year={2003},
  volume={102 5},
  pages={1745-52}
}
We have shown previously that primary dendritic cells and monocytes express equal levels of CD14 but are distinguishable by the presence of CD2 on dendritic cells. CD2 is known to mediate the activation of T and natural killer (NK) cells through its interaction with CD58. CD2 epitopes recognized by anti-T111, -T112, and -T113 monoclonal antibodies (mAbs) are present on dendritic cells. Here we show that CD2 engagement significantly increases class II, costimulatory (CD40, CD80, CD86), adhesion… CONTINUE READING

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