CD2 and CD8α define porcine γδ T cells with distinct cytokine production profiles.

@article{Sedlak2014CD2AC,
  title={CD2 and CD8α define porcine γδ T cells with distinct cytokine production profiles.},
  author={Corinna Sedlak and Martina Patzl and Armin Saalmueller and Wilhelm Gerner},
  journal={Developmental and comparative immunology},
  year={2014},
  volume={45 1},
  pages={97-106}
}
γδ T cells are a remarkably prominent T-cell subset in swine with a high prevalence in blood. Phenotypic analyses in this study showed that CD2(-) γδ T cells in their vast majority had a CD8α(-)SLA-DR(-)CD27(+) phenotype. CD2(+) γδ T cells dominated in spleen and lymph nodes and had a more heterogeneous phenotype. CD8α(+)SLA-DR(-)CD27(+) γδ T cells prevailed in blood, spleen and lymph nodes whereas in liver a CD8α(+)SLA-DR(+)CD27(-) phenotype dominated, indicating an enrichment of terminally… CONTINUE READING