CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA.

@article{Musgrave2004CD2CD48IP,
  title={CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA.},
  author={Bruce L Musgrave and Carrie L Watson and S M Mansour Haeryfar and Christine A. Barnes and David W. Hoskin},
  journal={Cellular immunology},
  year={2004},
  volume={229 1},
  pages={1-12}
}
CD2-CD48 interactions enhance T cell receptor-driven mouse T lymphocyte activation. However, the mechanism is not well understood. Here we show that blockade of CD2-CD48 interactions with anti-CD48 monoclonal antibody (mAb) inhibited interleukin (IL)-2 and interferon (IFN)-gamma expression, as well as T cell proliferation in response to mitogenic anti-CD3 mAb, although more potent inhibition resulted from blocking CD28-CD80/CD86 interactions. Blockade of both CD2 and CD28 costimulation… CONTINUE READING