CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

@article{Kanner1992CD2LFA3LI,
  title={CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.},
  author={Steven B. Kanner and Nitin K. Damle and James A Blake and Alejandro Aruffo and Jeffrey A. Ledbetter},
  journal={Journal of immunology},
  year={1992},
  volume={148 7},
  pages={2023-9}
}
Activation of T cells through the TCR/CD3 receptor complex with either specific Ag or antibody results in tyrosine phosphorylation of intracellular protein substrates and phosphatidylinositol-phospholipase C (PLC) signaling, leading to the generation of PI breakdown products and the mobilization of intracellular calcium. Stimulation of the T cell surface receptor CD2 similarly propagates early signals through phosphatidylinositol-PLC activation. Previous reports have shown that CD3 activation… CONTINUE READING

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