CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

@article{Spada1998CD1drestrictedRO,
  title={CD1d-restricted Recognition of Synthetic Glycolipid  Antigens by Human Natural Killer T Cells },
  author={Franca M. Spada and Yasuhiko Koezuka and Steven A. Porcelli},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={1529 - 1534}
}
A conserved subset of mature circulating T cells in humans expresses an invariant Valpha24-JalphaQ T cell receptor (TCR)-alpha chain rearrangement and several natural killer (NK) locus-encoded C-type lectins. These human T cells appear to be precise homologues of the subset of NK1.1(+) TCR-alpha/beta+ T cells, often referred to as NK T cells, which was initially identified in mice. Here we show that human NK T cell clones are strongly and specifically activated by the same synthetic glycolipid… CONTINUE READING
157 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 157 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…