CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

  title={CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung},
  author={Edward E. S. Nieuwenhuis and Tetsuya Matsumoto and Mark Exley and Robbert A. Schleipman and Jonathan Glickman and Dan T. Bailey and Nadia Corazza and Sean P Colgan and Andrew B. Onderdonk and Richard S Blumberg},
  journal={Nature Medicine},
CD1d-restricted T cells are implicated as key players in host defense against various microbial infections. However, the mechanisms involved and the role they play, if any, at the mucosal surfaces where pathogenic infections are initiated is unknown. In a murine pneumonia model established by intranasal application of Pseudomonas aeruginosa, CD1d−/− mice showed markedly reduced pulmonary eradication of P. aeruginosa compared with wild-type mice; this was associated with significantly lower… CONTINUE READING


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