CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

@inproceedings{Schiller2016CD19specificTS,
  title={CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells},
  author={Christian Schiller and Todd A. Braciak and Nadja C. Fenn and Ursula J{\"o}rdis Eva Seidel and Claudia C. Roskopf and Sarah Wildenhain and Annemarie Honegger and Ingo A. Schubert and Alexandra Schele and Kerstin L{\"a}mmermann and Georg H. Fey and Uwe Jacob and Peter A. Lang and Karl-Peter Hopfner and Fuat S. Oduncu},
  booktitle={Oncotarget},
  year={2016}
}
Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expressing cytolytic effectors, including NK and γδ T cells.SPM-1 is an optimized version of triplebody ds(19-16-19) and includes humanization, disulfide stabilization and the removal of potentially immunogenic sequences. A three-step chromatographic procedure… CONTINUE READING
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