CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

@article{Fujimoto2000CD19RS,
  title={CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.},
  author={M Fujimoto and Yoko Fujimoto and Jonathan C Poe and Paul J. Jansen and Clifford A Lowell and Anthony L DeFranco and Thomas F. Tedder},
  journal={Immunity},
  year={2000},
  volume={13 1},
  pages={47-57}
}
CD19 regulates constitutive and antigen receptor-induced signaling thresholds in B lymphocytes through its unique cytoplasmic domain. Herein, we demonstrate a novel molecular mechanism where interactions between CD19 and Lyn amplify basal and antigen receptor-induced Src family kinase activation. Lyn expression was required for CD19 tyrosine phosphorylation in primary B cells. Experiments with purified proteins demonstrated that CD19-Y513 was Lyn's initial phosphorylation and binding site. This… CONTINUE READING

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