CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.

  title={CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.},
  author={Eriko Saito and M Fujimoto and Minoru Hasegawa and Kazuhiro Komura and Yasuhito Hamaguchi and Yuko Kaburagi and Tetsuya Nagaoka and Kazuhiko Takehara and Thomas F. Tedder and Shinichi Sato},
  journal={The Journal of clinical investigation},
  volume={109 11},
The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although molecular mechanisms explaining the development of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknown, we recently demonstrated that SSc patients overexpress CD19, an important regulatory molecule expressed by B lymphocytes. B cells from CD19-deficient mice are hyporesponsive to transmembrane… CONTINUE READING


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