CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

@article{ORourke1998CD19AA,
  title={CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.},
  author={Leslie M. O'Rourke and Reuben M Tooze and Martin Turner and Dr. Milagros Sandoval and Robert H. Carter and Victor L. J. Tybulewicz and Douglas T Fearon},
  journal={Immunity},
  year={1998},
  volume={8 5},
  pages={635-45}
}
CD19 is a coreceptor that amplifies signaling by membrane immunoglobulin (mIg) to promote responses of the B lymphocyte to T-dependent antigens. Vav is a guanine nucleotide exchange factor for the Rho, Rac, Cdc42 family of small GTPases. We found that coligating mIg and CD19 causes a synergistic increase in the tyrosine phosphorylation of CD19. Phosphorylated tyrosine-391 of CD19 binds Vav to mediate a sustained increase in intracellular Ca2+ concentration. This response correlates with… CONTINUE READING
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