CD18 and ICAM-1-dependent corneal neovascularization and inflammation after limbal injury.

  title={CD18 and ICAM-1-dependent corneal neovascularization and inflammation after limbal injury.},
  author={Y. Moromizato and S. Stechschulte and K. Miyamoto and T. Murata and A. Tsujikawa and A. Joussen and A. P. Adamis},
  journal={The American journal of pathology},
  volume={157 4},
  • Y. Moromizato, S. Stechschulte, +4 authors A. P. Adamis
  • Published 2000
  • Biology, Medicine
  • The American journal of pathology
  • Extensive limbal injury is a leading cause of irreversible blindness. The destruction of corneal limbal stem cells often results in corneal neovascularization and an optically inferior epithelium. Previous work has shown that the neovascularization after limbal injury is vascular endothelial growth factor (VEGF)-dependent, with much of the VEGF emanating from the inflammatory cells that invade the cornea. Using a relevant mouse model of limbal injury, we examined the role of CD18 and… CONTINUE READING
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