CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma.

@article{Ohnishi2013CD169positiveMI,
  title={CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma.},
  author={Koji Ohnishi and Yoshihiro Komohara and Yoichi Saito and Yuji Miyamoto and Masayuki Watanabe and Hideo Baba and Motohiro Takeya},
  journal={Cancer science},
  year={2013},
  volume={104 9},
  pages={
          1237-44
        }
}
CD169 (sialoadhesin) is a sialic acid receptor that is expressed on specific macrophages such as lymph node sinus macrophages. Animal studies have suggested that CD169(+) macrophages have a pro-inflammatory property, however, the role of these cells in human diseases has not been clarified. In our in vitro experiments with human macrophages, pro-inflammatory cytokines, such as type 1 interferon, induced strong expression of CD169, suggesting that CD169 might be a specific marker of inflammatory… CONTINUE READING

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