CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.

@article{Asano2011CD169positiveMD,
  title={CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.},
  author={Kenichi Asano and Ami Nabeyama and Yasunobu Miyake and Chun-Hong Qiu and Ai Kurita and Michio Tomura and Osami Kanagawa and Shin-ichiro Fujii and Masato Tanaka},
  journal={Immunity},
  year={2011},
  volume={34 1},
  pages={85-95}
}
The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the induction of antitumor immunity. To activate these CD8(+) T cells, antigen-presenting cells (APCs) must initially acquire tumor cell-associated antigens. The major source of tumor antigens is dead tumor cells, but little is known about how APCs in draining lymph nodes acquire and crosspresent these antigens. Here we show that CD169(+) macrophages phagocytose dead tumor cells transported via lymphatic flow and… CONTINUE READING