CD169(+) macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer.

@article{Wu2016CD169MM,
  title={CD169(+) macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer.},
  author={Andy Chiu-Ku Wu and Yaowu He and Amy Broomfield and Nicoll J Paatan and Brittney S Harrington and Hsu-Wen Tseng and Elizabeth A Beaven and Deirdre Margaret Kiernan and Peter Swindle and Adrian B Clubb and J L{\'e}vesque and Ingrid G Winkler and M T P Ling and Bhuvana Srinivasan and John David Hooper and Allison R Pettit},
  journal={The Journal of pathology},
  year={2016},
  volume={239 2},
  pages={218-30}
}
Skeletal metastases present a major clinical challenge for prostate cancer patient care, inflicting distinctive mixed osteoblastic and osteolytic lesions that cause morbidity and refractory skeletal complications. Macrophages are abundant in bone and bone marrow and can influence both osteoblast and osteoclast function in physiology and pathology. Herein, we examined the role of macrophages in prostate cancer bone lesions, particularly the osteoblastic response. First, macrophage and lymphocyte… CONTINUE READING
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