CD169+ macrophages at the crossroads of antigen presentation.

  title={CD169+ macrophages at the crossroads of antigen presentation.},
  author={Luisa Martinez-Pomares and Siamon Gordon},
  journal={Trends in immunology},
  volume={33 2},
CD169(+) macrophages have fascinated immunologists because of their unique distribution in secondary lymphoid organs, redistribution upon immune activation and, lately, because of their contribution to antigen handling. Their association with B cell follicles prompted early studies on their involvement in B cell activation, and recent work has unveiled an unexpected role in facilitating activation of other lymphocyte subsets, such as invariant natural killer T (iNKT) cells. New data also argue… CONTINUE READING
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