CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche.

@article{Chitteti2014CD166RH,
  title={CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche.},
  author={Brahmananda Chitteti and Michihiro Kobayashi and Yinghua Cheng and Huajia Zhang and Bradley A. Poteat and Hal E. Broxmeyer and Louis M. Pelus and Helmut Hanenberg and Amy L. Zollman and Malgorzata M. Kamocka and Nadia Carlesso and Angelo Almeida Cardoso and Melissa A. Kacena and Edward F Srour},
  journal={Blood},
  year={2014},
  volume={124 4},
  pages={519-29}
}
We previously showed that immature CD166(+) osteoblasts (OB) promote hematopoietic stem cell (HSC) function. Here, we demonstrate that CD166 is a functional HSC marker that identifies both murine and human long-term repopulating cells. Both murine LSKCD48(-)CD166(+)CD150(+) and LSKCD48(-)CD166(+)CD150(+)CD9(+) cells, as well as human Lin(-)CD34(+)CD38… CONTINUE READING
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