CD16 promotes Escherichia coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis and facilitates inflammation

@article{Silva2007CD16PE,
  title={CD16 promotes Escherichia coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis and facilitates inflammation},
  author={Fabiano Pinheiro da Silva and Meryem Aloulou and David Skurnik and M. Benhamou and Antoine Andremont and Irineu Tadeu Velasco and Murilo Chiamolera and J. Sjef Verbeek and Pierre Launay and Renato C Monteiro},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={1368-1374}
}
Sepsis, a leading cause of death worldwide, involves proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial part in the prevention of sepsis by clearing bacteria through host innate receptors. Here we show that the FcRγ adaptor, an immunoreceptor tyrosine-based activation motif (ITAM)-bearing signal transduction subunit of the Fc receptor family, has a deleterious effect on sepsis. FcRγ−/− mice show increased survival during peritonitis, owing to markedly… CONTINUE READING

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