CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.

@article{Ancuta2006CD16MM,
  title={CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.},
  author={Petronela Ancuta and Patrick J. Autissier and Alysse G Wurcel and Tauheed M. Zaman and David Stone and Dana Gabuzda},
  journal={Journal of immunology},
  year={2006},
  volume={176 10},
  pages={5760-71}
}
The CD16(+) monocyte (Mo) subset produces proinflammatory cytokines and is expanded in peripheral blood during progression to AIDS, but its contribution to HIV pathogenesis is unclear. In this study, we investigate the capacity of human CD16(+) and CD16(-) Mo subsets to render resting CD4(+) T cells permissive for HIV replication. We demonstrate that CD16(+) Mo preferentially differentiate into macrophages (Mphi) that activate resting T cells for productive HIV infection by producing the CCR3… CONTINUE READING

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