CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells.

@article{SnchezTorres2001CD16AC,
  title={CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells.},
  author={Carmen S{\'a}nchez-Torres and Gina Stella Garc{\'i}a-Romo and Miguel A Cornejo-Cort{\'e}s and Amaranta Rivas-Carvalho and Guzman Sanchez-Schmitz},
  journal={International immunology},
  year={2001},
  volume={13 12},
  pages={1571-81}
}
Experimental protocols for cancer immunotherapy include the utilization of autologous monocyte-derived dendritic cells (moDC) pulsed with tumor antigens. However, disease can alter the characteristics of monocyte precursors and some patients have increased numbers (up to 40%) of the minor CD16(+) monocyte subpopulation, which in healthy individuals represent 10% of blood monocytes. At the present, the capacity of CD16(+) monocytes to differentiate into DC has not been evaluated. Here, we… CONTINUE READING

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