CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.

@article{Sloan2005CD155PVREG,
  title={CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.},
  author={Kevin E. Sloan and Jean K. Stewart and Allison F Treloar and Russell Thomas Matthews and Daniel G. Jay},
  journal={Cancer research},
  year={2005},
  volume={65 23},
  pages={10930-7}
}
We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enhances their dispersal both in vitro and on primary brain tissue. CD155/PVR expression also reduced substrate adhesion, cell spreading, focal adhesion density, and the number of… CONTINUE READING

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