CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses.

@article{Straw2003CD154PA,
  title={CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses.},
  author={Amy D. Straw and Andrew S MacDonald and Eric Y. Denkers and Edward J. Pearce},
  journal={Journal of immunology},
  year={2003},
  volume={170 2},
  pages={727-34}
}
We compared splenic DC activation during infection with either the Th2 response-inducing parasite Schistosoma mansoni or with the Th1 response-inducing parasite Toxoplasma gondii. CD8alpha(+) DC from schistosome-infected mice exhibited a 2- to 3-fold increase in the expression of MHC class II, CD80, and CD40 (but not CD86) compared with DC from uninfected control animals, while CD8alpha(-) DC exhibited a 2- to 3-fold increase in the expression of MHC class II and CD80 and no alteration… CONTINUE READING

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