CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function.

@article{Zhao2013CD147PM,
  title={CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function.},
  author={Shuang Zhao and Chen Chen and Shuang Liu and Weiqi Zeng and Juan Su and Lisha Wu and Zhongling Luo and Shuangyuan Zhou and Qingling Li and Jianglin Zhang and Yehong Kuang and Xiang Chen},
  journal={Journal of dermatological science},
  year={2013},
  volume={70 3},
  pages={182-9}
}
BACKGROUND Methotrexate (MTX) is a drug used to treat psoriasis due to inducing immune cell apoptosis. However, certain patients show MTX resistant. CD147, highly expressed by psoriatic PBMCs, is assumed to regulate MTX sensitivity. The underlining mechanism is still relatively understudied. OBJECTIVE To understand the mechanisms of that CD147 promotes MTX resistance in immune cells. METHODS The expression of CD147 and ABCG2 in PBMCs from psoriatic patients, cellular apoptosis and… CONTINUE READING
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