CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma.

@article{Ishibashi2004CD147AM,
  title={CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma.},
  author={Yoshio Ishibashi and Tomoe Matsumoto and Mikio Niwa and Yutaka Suzuki and Nobuo Omura and Nobuyoshi Hanyu and Koji Nakada and Katsuhiko Yanaga and Kyosuke Yamada and Kiyoshi Ohkawa and Makio Kawakami and Mitsuyoshi Urashima},
  journal={Cancer},
  year={2004},
  volume={101 9},
  pages={1994-2000}
}
BACKGROUND The authors investigated whether the presence of matrix metalloproteinase-2 (MMP-2) and its inducer, CD147, in cancerous esophageal lesions and surrounding tissue might help to predict patient prognosis. METHODS Tissue samples from 101 patients with esophageal squamous cell carcinoma were stained with anti-CD147 and anti-MMP-2 antibodies for immunohistochemical analysis. RESULTS CD147 was expressed in cancerous and dysplastic lesions, but not in normal tissue. In contrast, MMP-2… CONTINUE READING

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