CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma.

Abstract

The signaling pathways facilitating metastasis of head and neck squamous cell carcinoma (HNSCC) cells are not fully understood. CD147 is a transmembrane glycoprotein known to induce cell migration and invasion. AGR2 is a secreted peptide also known to promote cell metastasis. Here we describe their importance in the migration and invasion of HNSCC cells (FADU and OSC-19) in vitro and in vivo. In vitro, knockdown of CD147 or AGR2 decreased cellular proliferation, migration and invasion. In vivo, knockdown of CD147 or AGR2 expression decreased primary tumor growth as well as regional and distant metastasis.

DOI: 10.1016/j.yexcr.2012.04.022
010020030020132014201520162017
Citations per Year

328 Citations

Semantic Scholar estimates that this publication has 328 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Sweeny2012CD147AA, title={CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma.}, author={Larissa Sweeny and Zhiyong Liu and Benjamin D Bush and Yolanda E. Hartman and Tong Zhou and Eben Lloyd Rosenthal}, journal={Experimental cell research}, year={2012}, volume={318 14}, pages={1788-98} }