CD146 and its soluble form regulate monocyte transendothelial migration.

  title={CD146 and its soluble form regulate monocyte transendothelial migration.},
  author={Nathalie Bardin and Marcel Blot-Chabaud and Nicolas Despoix and Abdeldjalil Kebir and Karim Harhouri and J. P. Arsanto and Leon Tellez Espinosa and Pierre Perrin and St{\'e}phane Robert and Fr{\'e}d{\'e}ric V{\'e}ly and Florence Sabatier and Andr{\'e} Le Bivic and Gilles Kaplanski and Jos{\'e} Sampol and Françoise Dignat-George},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={29 5},
OBJECTIVES During inflammation, cell adhesion molecules are modulated or redistributed for leukocyte transmigration. Among molecules at the interendothelial junction, CD146 is involved in cell-cell cohesion and permeability, but its role in monocyte transmigration is unknown. METHODS AND RESULTS TNF enhanced CD146 expression at the junction and apical membrane of human umbilical veins endothelial cells (HUVECs) through CD146 synthesis and intracellular store redistribution. In addition, TNF… CONTINUE READING
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