CD140a identifies a population of highly myelinogenic, migration-competent, and efficiently engrafting human oligodendrocyte progenitor cells

@inproceedings{Sim2011CD140aIA,
  title={CD140a identifies a population of highly myelinogenic, migration-competent, and efficiently engrafting human oligodendrocyte progenitor cells},
  author={Fraser James Sim and Crystal R McClain and Steven J. Schanz and Tricia L. Protack and Martha S. Windrem and Steven A Goldman},
  booktitle={Nature Biotechnology},
  year={2011}
}
Experimental animals with myelin disorders can be treated by transplanting oligodendrocyte progenitor cells (OPCs) into the affected brain or spinal cord. OPCs have been isolated by their expression of gangliosides recognized by mAb A2B5, but this marker also identifies lineage-restricted astrocytes and immature neurons. To establish a more efficient means of isolating myelinogenic OPCs, we sorted fetal human forebrain cells for CD140a, an epitope of platelet derived growth factor receptor… CONTINUE READING