CD14 signalling in lipid rafts: new ligands and co-receptors.

  title={CD14 signalling in lipid rafts: new ligands and co-receptors.},
  author={Gerd Schmitz and Evelyn Orso},
  journal={Current opinion in lipidology},
  volume={13 5},
PURPOSE OF REVIEW Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis. RECENT FINDINGS Upon binding of various ligands, CD14 as a multiligand pattern… CONTINUE READING

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