CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

@article{Zanoni2009CD14RT,
  title={CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation},
  author={Ivan Zanoni and Renato Ostuni and Giusy Capuano and Maddalena Collini and Michele Caccia and Antonella Ellena Ronchi and Marcella Rocchetti and Francesca Mingozzi and Maria Foti and Giuseppe Chirico and Barbara Costa and Antonio Zaza and Paola Ricciardi-Castagnoli and Francesca Granucci},
  journal={Nature},
  year={2009},
  volume={460},
  pages={264-268}
}
Toll-like receptors (TLRs) are the best characterized pattern recognition receptors. Individual TLRs recruit diverse combinations of adaptor proteins, triggering signal transduction pathways and leading to the activation of various transcription factors, including nuclear factor κB, activation protein 1 and interferon regulatory factors. Interleukin-2 is one of the molecules produced by mouse dendritic cells after stimulation by different pattern recognition receptor agonists. By analogy with… CONTINUE READING

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