CD14 is a key organizer of microglial responses to CNS infection and injury.

  title={CD14 is a key organizer of microglial responses to CNS infection and injury.},
  author={Hana Janova and Chotima Boettcher and Inge R Holtman and Tommy Regen and Denise van Rossum and Alexander A G{\"o}tz and Anne-Sophie Ernst and Christin Fritsche and Ulla Gertig and Nasrin Saiepour and Konrad Gronke and Claudia Wrzos and Sandra Ribes and Simone Rolfes and Jonathan R Weinstein and Hannelore Ehrenreich and Tobias Pukrop and Jens Christopher Kopatz and Christine Stadelmann and Gabriela Salinas-Riester and Martin S. Weber and Marco Prinz and Wolfgang Br{\"u}ck and Bart J. L. Eggen and Hendrikus W. G. M. Boddeke and Josef Priller and U. -K. Hanisch},
  volume={64 4},
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll-like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and multiple injury-associated factors. We show that its co-receptor CD14 serves three non-redundant functions in microglia. First, it confers an up to 100-fold higher LPS sensitivity compared to peripheral macrophages to enable efficient proinflammatory cytokine induction. Second, CD14 prevents excessive responses to… CONTINUE READING
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