CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.

@article{Cheah2015CD14expressingCC,
  title={CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.},
  author={Ming T. Cheah and James Yok-Jen Chen and Debashis Sahoo and Humberto Contreras-Trujillo and Anne K Volkmer and Ferenc A Scheeren and Jens-Peter Volkmer and Irving L Weissman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 15},
  pages={4725-30}
}
Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) as a model, we found that CD14-high cancer cells express higher levels of numerous inflammation mediators and form larger tumors compared with CD14-low cells. CD14 antigen is a glycosyl… CONTINUE READING