CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.

@article{Perera1997CD14dependentAC,
  title={CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.},
  author={Pradeep Perera and Stefanie N. Vogel and G R Detore and Alain Haziot and Sanna M. Goyert},
  journal={Journal of immunology},
  year={1997},
  volume={158 9},
  pages={4422-9}
}
The antitumor agent, Taxol, shares with bacterial LPS the ability to activate murine macrophages, and its LPS-mimetic effects are blocked by LPS analogue antagonists. Since CD14 is central to the recognition of LPS by macrophages, we sought to examine a role for CD14 in the response to Taxol vs LPS. A comparison of responses of macrophages from wild-type mice with those from mice lacking CD14 due to a targeted disruption of the CD14 gene (CD14-deficient knockout (CD14KO)) revealed that like LPS… CONTINUE READING

From This Paper

Topics from this paper.
75 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…