CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

@article{Rajaiah2015CD14DO,
  title={CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.},
  author={R. Preethi Rajaiah and Darren J. Perkins and Derek D C Ireland and Stefanie N. Vogel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 27},
  pages={8391-6}
}
Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) heterodimers is critical for both MyD88- and TIR-domain-containing adapter-inducing IFN-β (TRIF)-mediated signaling pathways. Recently, Zanoni et al. [(2011) Cell 147(4):868-880] reported that cluster of differentiation 14 (CD14) is required for LPS-/Escherichia coli- induced TLR4 internalization into endosomes and activation of TRIF-mediated signaling in macrophages. We confirmed their findings with LPS but… CONTINUE READING
Highly Cited
This paper has 276 citations. REVIEW CITATIONS

4 Figures & Tables

Topics

Statistics

0100200300201620172018
Citations per Year

277 Citations

Semantic Scholar estimates that this publication has 277 citations based on the available data.

See our FAQ for additional information.