CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection.

@article{Echchannaoui2005CD14DL,
  title={CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection.},
  author={Hakim Echchannaoui and Karl Frei and Maryse Letiembre and Robert M. Strieter and Yoshiyuki Adachi and R{\'e}gine Landmann},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 3},
  pages={705-15}
}
CD14 is a myeloid receptor for bacterial cell membrane/wall components, for which we previously showed a strong induction in cerebrospinal fluid (CSF) during meningitis. Here, we studied CD14 function in murine Streptococcus pneumoniae meningitis by using wild-type (WT), CD14(-/-) mice, and WT mice pretreated with neutralizing anti-CD14 antibodies. Early… CONTINUE READING