CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis.

@article{Labta1993CD14AT,
  title={CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis.},
  author={Mario O. Lab{\'e}ta and Jacques Durieux and Giulio Spagnoli and Nieves Fern{\'a}ndez and John Wijdenes and Robert L. Herrmann},
  journal={Immunology},
  year={1993},
  volume={80 3},
  pages={415-23}
}
To evaluate the role of the high-affinity monocyte receptor for lipopolysaccharide (LPS), CD14, in the process of tolerance to LPS, the human monocytic cell line Mono-Mac-6 was cultured in the absence or presence of different amounts of LPS. The kinetics of CD14 modulation in these cells showed an initial 4-day period characterized by increased cell-surface expression, rate of biosynthesis (peaking at 48 hr) and release of its soluble forms (sCD14) which correlated with the amount of LPS in the… CONTINUE READING

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