CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.

@article{Regen2011CD14AT,
  title={CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.},
  author={Tommy Regen and Denise van Rossum and J{\"o}rg Scheffel and Maria-Eleni Kastriti and Natalia H Revelo and Marco Prinz and Wolfgang Brueck and U. -K. Hanisch},
  journal={Brain, behavior, and immunity},
  year={2011},
  volume={25 5},
  pages={957-70}
}
Toll-like receptor (TLR) 4 responds to a range of agonists in infection and injury, but is best known for the recognition of bacterial lipopolysaccharides (LPS). Assembly in heterologous receptor complexes as well as signaling through both MyD88 and TRIF adaptor proteins, as unmatched by other TLRs, could underlie its versatile response options, probably also in a cell type-dependent manner. We show that microglia, the CNS macrophages, react to diverse LPS variants, including smooth (S) and… CONTINUE READING