CD14 and TLR4 gene polymorphisms in adult periodontitis.

@article{Laine2005CD14AT,
  title={CD14 and TLR4 gene polymorphisms in adult periodontitis.},
  author={M L Laine and Servaas A Morr{\'e} and Laura S. Murillo and A-J van Winkelhoff and A. Salvador Pe{\~n}a},
  journal={Journal of dental research},
  year={2005},
  volume={84 11},
  pages={1042-6}
}
Bacterial deposits, smoking, and host genetic factors play a major role in an individual's predisposition to periodontitis. Bacterial components are recognized by CD14 and toll-like receptor 4 (TLR4), resulting in a NF-kappaB-based inflammatory response. We hypothesized that functional CD14 and TLR4 polymorphisms contribute to periodontitis susceptibility. We aimed to investigate the occurrence of CD14-260C>T, TLR4 299Asp>Gly, and 399Thr>Ile gene polymorphisms in adult periodontititis. DNA was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…