CD14 and TLR4 gene polymorphisms in adult periodontitis.

  title={CD14 and TLR4 gene polymorphisms in adult periodontitis.},
  author={M L Laine and Servaas A Morr{\'e} and Laura S. Murillo and A-J van Winkelhoff and A. Salvador Pe{\~n}a},
  journal={Journal of dental research},
  volume={84 11},
Bacterial deposits, smoking, and host genetic factors play a major role in an individual's predisposition to periodontitis. Bacterial components are recognized by CD14 and toll-like receptor 4 (TLR4), resulting in a NF-kappaB-based inflammatory response. We hypothesized that functional CD14 and TLR4 polymorphisms contribute to periodontitis susceptibility. We aimed to investigate the occurrence of CD14-260C>T, TLR4 299Asp>Gly, and 399Thr>Ile gene polymorphisms in adult periodontititis. DNA was… CONTINUE READING


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