CD14 Signaling Restrains Chronic Inflammation through Induction of p38-MAPK/SOCS-Dependent Tolerance

@inproceedings{Sahay2009CD14SR,
  title={CD14 Signaling Restrains Chronic Inflammation through Induction of p38-MAPK/SOCS-Dependent Tolerance},
  author={Bikash Sahay and Rebeca L. Patsey and Christian H. Eggers and Juan P. Salazar and Justin D. Radolf and Timothy J. Sellati},
  booktitle={PLoS pathogens},
  year={2009}
}
Current thinking emphasizes the primacy of CD14 in facilitating recognition of microbes by certain TLRs to initiate pro-inflammatory signaling events and the importance of p38-MAPK in augmenting such responses. Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia burgdorferi not only triggers an inflammatory response in the absence of CD14, but one that is, in part, a consequence of altered PI3K/AKT/p38-MAPK signaling and impaired negative regulation of TLR2… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 107 references

The biology of p38 kinase: a central role in inflammation.

Current topics in medicinal chemistry • 2005
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…