CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert.

  • Yuwen Zhu, L Chen
  • Published 2014 in
    Clinical cancer research : an official journal of…


Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor. 
DOI: 10.1158/1078-0432.CCR-13-2573


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