CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation.

@article{Vidard2019CD137E,
  title={CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation.},
  author={Laurent Vidard and Christine Dureuil and J{\'e}r{\'e}my Baudhuin and Lionel Vescovi and Laurence Durand and V{\'e}ronique Sierra and Eric Parmantier},
  journal={Journal of immunology},
  year={2019}
}
To understand and dissect the mechanisms driving human NK cell proliferation, we exploited the methodology used in cell therapy to numerically expand NK cells in the presence of K562-derived artificial APC (aAPCs) and cytokines. For four consecutive weeks, high expression of CD137L by a K562-derived aAPC cell line could sustain NK cell expansion by 3 × 105-fold, whereas low expression of CD137L by the parental K562 cell line only supported the expansion by 2 × 103-fold. The level of expression… CONTINUE READING
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