CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures

@inproceedings{Nowak2018CD137CD154EA,
  title={CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures},
  author={Anna K. Nowak and Dominik Peter Lock and Petra Bacher and Thordis Hohnstein and Katrin Vogt and Judith Gottfreund and Pascal Giehr and Julia K. Polansky and B Sawitzki and Andrew Kaiser and J{\"o}rn Walter and Alexander Scheffold},
  booktitle={Front. Immunol.},
  year={2018}
}
Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g., via genetic engineering of their antigen receptors. However, purity of clinical Treg expansion cultures is highly variable, and currently, it is impossible to identify and separate stable Tregs from contaminating effector T cells, either ex vivo… CONTINUE READING
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