CD133 positive U87 glioblastoma cells-derived exosomal microRNAs in hypoxia- versus normoxia-microenviroment

@article{Zhang2017CD133PU,
  title={CD133 positive U87 glioblastoma cells-derived exosomal microRNAs in hypoxia- versus normoxia-microenviroment},
  author={Guobin Zhang and Yunsheng Zhang and Sen Sung Cheng and Zhen Wu and Fusheng Liu and Junting Zhang},
  journal={Journal of Neuro-Oncology},
  year={2017},
  volume={135},
  pages={37-46}
}
Hypoxia is a major regulator of glioma development and aggressiveness. However, how CD133 positive U87 glioblastoma cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Communication with host cells and stroma via exosomes represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. MicroRNAs are thought to be essential actors of tumorigenesis as they are able to… CONTINUE READING
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